Comic Book Resources has posted an interview with "Spider-Man" franchise director Sam Raimi in which he reiterates that what happens in the fourth installment will be up to the writer they are hiring, including the villain(s). Here's a bit from the piece:
Sam: If I was writing it I would have a very strong opinion about that, but we're hiring a writer to come up with his own take. Sony was willing to go either way, we'll just have to wait and see what the writer comes up with. I think anything's possible, though.
I mean, there's been so many different versions, it doesn't have to follow the movies that we've made. I'd very much like to see Tobey Maguire as Spider-Man, so I have a personal interest in that, but certainly anything's possible. Spider-Man's such a big character in the comic books that he could endure a lot of different interpretations. You could start over or you could start with a different aspect of the story than I've focused on in the pictures I've made, we'll just have to wait and see what the writer comes up with.
Hit the link above for the full interview.
Special thanks to Spider-Man Hype for the heads up, and Comic Book Resources for the interview.