Would Elizabeth Banks return as Betty Brant in a fourth and/or fifth "Spider-Man" movie? It doesn't sound like it, as she tells CHUD:
"If it's that small, I probably won't do it. They don't need Betty Brant. It's purely, at this point - and I don't think they see it this way - it's kind of a favor at this point."
She talks more about how she landed the role at the link above!
Sources: CHUD, and Superhero Hype!